Extracellular Targeting of Cell Signaling in Cancer: Strategies Directed at MET and RON Receptor Tyrosine Kinase Pathways — 2018 PDF

📘 Extracellular Targeting of Cell Signaling in Cancer: Strategies Directed at MET and RON Receptor Tyrosine Kinase Pathways — 2018 PDF

🔎 About This Medical eBook

This specialist research volume examines extracellular approaches to targeting the MET and RON signaling pathways in cancer. It connects receptor biology, growth-factor activation and protease activity with the development of experimental therapeutic strategies. The emphasis is on mechanisms and drug discovery rather than a general clinical treatment manual.

Topics covered

• HGF/MET and MSP/RON signaling mechanisms.
• Tumor progression and resistance to anticancer therapy.
• HGF activator and its endogenous inhibitors.
• Matriptase and hepsin in cancer biology.
• Antibodies directed at growth factors, receptors and proteases.
• Rational design and optimization of protease inhibitors.

Reading focus

The chapters move from pathway discovery and physiological function to potential points of therapeutic intervention. This structure helps readers understand why extracellular activation processes may offer targets in addition to the intracellular kinase itself. Discussions of antibodies and small-molecule strategies connect biological rationale with development challenges. The volume reflects research available for its 2018 publication and is most useful as a focused foundation for evaluating subsequent work on these signaling systems.

Intended readership

Cancer biologists, medicinal chemists, molecular pathologists, translational researchers and postgraduate students studying receptor signaling or oncology drug discovery.

Publication and PDF details

James W. Janetka and Roseann M. Benson (editors). Publication year: 2018. English language. One PDF file with 476 digital pages, including preliminary material. ISBN: 9781119300205.

Digital PDF

This is a digital ebook in PDF format. After downloading, it can be read offline using a compatible PDF reader on a computer, tablet or phone. The digital page total may differ from printed pagination. The download contains the PDF described here; printed copies and separately activated online resources are not included.

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